Promethazine is metabolized via the liver to many different compounds; the sulfoxides of promethazine and N-demethylpromethazine are the predominant metabolites appearing within the urine.
Excessively big dosages of antihistamines, which include promethazine hydrochloride, in pediatric individuals may possibly bring about unexpected Loss of life (see OVERDOSAGE). Hallucinations and convulsions have occurred with therapeutic doses and overdoses of promethazine hydrochloride in pediatric sufferers. In pediatric individuals that are acutely sick related to dehydration, there is an elevated susceptibility to dystonias with the usage of promethazine HCl.
Sedation in equally little ones and Older people, and aid of apprehension and creation of mild slumber from which the affected person could be very easily aroused.
The following really serious adverse reactions are described, or explained in greater depth, in other sections:
Unique research to test the action on the drug on parturition, lactation, and progress of the animal neonate weren't carried out, but a basic preliminary examine in rats indicated no effect on these parameters.
Neuroleptic malignant syndrome (NMS) which can result in Loss of life. Let you know quagen pharma promethazine Health care provider without delay Should you have any of the following signs of NMS:
There's no standard arrangement about unique pharmacological treatment regimens for uncomplicated NMS.
Extended-time period animal studies haven't been done to evaluate the carcinogenic potential of Promethazine, nor are there other animal or human details relating to carcinogenicity, mutagenicity, or impairment of fertility using this type of drug. Promethazine was nonmutagenic in the Salmonella take a look at system of Ames.
Sedation This solution relieves apprehension and induces a quiet slumber from which the client could be effortlessly aroused.
It's tricky to ascertain what constitutes a regular toxic or lethal dose. Having said that, the lethal oral dose of codeine in an adult is reported for being while in the array of 0.
Postmarketing situations of respiratory depression, together with fatalities, are noted with usage of promethazine hydrochloride in pediatric individuals fewer than 2 decades of age. An array of weight-based mostly doses of promethazine hydrochloride have resulted in respiratory despair in these individuals.
Pediatric sufferers really should be supervised to avoid prospective damage in bike Using or in other dangerous functions.
Simply because opioid agonists may maximize biliary tract force, with resultant increase in plasma amylase or lipase levels, resolve of those enzyme levels might be unreliable for twenty-four hours just after administration of a dose of Promethazine HCl and Codeine Phosphate Oral Solution.
Sedation in both of those little ones and Grownups, in addition to relief of apprehension and production of mild rest from which the affected individual may be effortlessly aroused.